Mediator kinases and CDK8-Mediator, Taatjes Lab

A Selective and Orally Bioavailable Quinoline-6-Carbonitrile-Based Inhibitor of CDK8/19 Mediator Kinase with Tumor-Enriched Pharmacokinetics

Frontiers Antagonizing CDK8 Sensitizes Colorectal Cancer to Radiation Through Potentiating the Transcription of e2f1 Target Gene apaf1

Mediator Kinase Inhibitors

Transcriptional Responses to IFN-γ Require Mediator Kinase-Dependent Pause Release and Mechanistically Distinct CDK8 and CDK19 Functions. - Abstract - Europe PMC

A precisely positioned MED12 activation helix stimulates CDK8 kinase activity

The Mediator complex: a central integrator of transcription

Inhibition of CDK8 mediator kinase suppresses estrogen dependent transcription and the growth of estrogen receptor positive breast cancer

Structure and noncanonical Cdk8 activation mechanism within an Argonaute-containing Mediator kinase module

Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases

Transcription Factors and PIC function, Taatjes Lab

Cooperative activity of cdk8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3

CDK8 inhibitors antagonize HIV-1 reactivation and promote provirus latency in T cells

Background, Taatjes Lab

The cyclin-dependent kinase 8 module sterically blocks Mediator interactions with RNA polymerase II

Structure and noncanonical Cdk8 activation mechanism within an Argonaute-containing Mediator kinase module