Chemical structure of AG10. The molecular formula of AG10

Download scientific diagram | Chemical structure of AG10. The molecular formula of AG10 (3-[3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy]-4-fluorobenzoic acid) is C 15 H 17 FN 2 O 3 , and its molecular weight is 292.13; the molecular formula of the hydrochloride salt (drug substance) is C 15 H 18 FClN 2 O 3 , and its molecular weight is 328.77. from publication: First‐in‐Human Study of AG10, a Novel, Oral, Specific, Selective, and Potent Transthyretin Stabilizer for the Treatment of Transthyretin Amyloidosis: A Phase 1 Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Study in Healthy Adult Volunteers | AG10 is a novel, potent, and selective oral transthyretin (TTR) stabilizer being developed to treat TTR amyloidosis (ATTR). This randomized, double‐blind, placebo‐controlled study evaluated safety, tolerability, pharmacokinetics, and pharmacodynamics (ex vivo stabilization) | Amyloidosis, Volunteering and Pharmacokinetics | ResearchGate, the professional network for scientists.

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Chemical structure of AG10. The molecular formula of AG10

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First‐in‐Human Study of AG10, a Novel, Oral, Specific, Selective

Enthalpy-Driven Stabilization of Transthyretin by AG10 Mimics a